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Literature summary for 2.4.2.30 extracted from

  • Guo, T.; Zuo, Y.; Qian, L.; Liu, J.; Yuan, Y.; Xu, K.; Miao, Y.; Feng, Q.; Chen, X.; Jin, L.; Zhang, L.; Dong, C.; Xiong, S.; Zheng, H.
    ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase beta-TrCP (2019), Nat. Microbiol., 4, 1872-1884 .
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
olaparib
-
 Homo sapiens
rucaparib
-
 Homo sapiens
veliparib
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + (ADP-D-ribosyl)n-beta-transducin repeat-containing protein Homo sapiens
-
 nicotinamide + (ADP-D-ribosyl)n+1-beta-transducin repeat-containing protein + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + (ADP-D-ribosyl)n-beta-transducin repeat-containing protein
-
 Homo sapiens nicotinamide + (ADP-D-ribosyl)n+1-beta-transducin repeat-containing protein + H+
-
 ?

Subunits

Subunits Comment Organism
? x * 40000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
ADP-ribosyltransferase
-
 Homo sapiens
PARP11
-
 Homo sapiens
poly(ADP-ribose) polymerase family member 11
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme expression is upregulated by virus infections, including vesicular stomatitis virus, herpes simplex virus-1 and influenza A virus, thus promoting ADP-ribosylation-mediated viral evasion up

General Information

General Information Comment Organism
physiological function the enzyme is a potent regulator of interferon-I antiviral efficacy. The enzyme inhibits the interferon-I-activated signalling pathway. Mono-ADP-ribosylation of beta-transducin repeat-containing protein promotes interferon alpha/beta receptor subunit 1 ubiquitination and degradation Homo sapiens